High-dose thiamine as initial treatment for Parkinson's disease.

An open-label pilot study with high-dose thiamine in Parkinson's disease

Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study.

OBJECTIVES To investigate the potential clinical, restorative, and neuroprotective effects of long-term treatment with thiamine in Parkinson disease (PD). DESIGN Observational open-label pilot study. SETTING Outpatient neurologic rehabilitation clinic. PATIENTS AND METHODS Starting in June 2012, we have recruited 50 patients with PD (33 men and 17 women; mean age, 70.4 ± 12.9 years; mean ...

Pemphigus Vulgaris Recurrence Rate and its Relationship with Initial Corticosteroid Dose

Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease with a high rate of morbidity and mortality without treatment. Until now, treatments consist mostly of the use of corticosteroid and immunosuppressive drugs. Optimum dosage for corticosteroid therapy is yet to be determined. The aim of the present study was to clear whether different initial corticosteroid therape...

The effects of aqueous cinnamon bark extract and cinnamaldehyde on neurons of substantia nigra and behavioral impairment in a mouse model of Parkinson’s disease

Background and Objective: Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. In recent years, there have been interests in the role of the free radical damage in PD. Cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. This research focused on the effects of cinnamon extract and cinnamald...

High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice

SLC19A3 deficiency, also called thiamine metabolism dysfunction syndrome-2 (THMD2; OMIM 607483), is an autosomal recessive neurodegenerative disorder caused by mutations in SLC19A3, the gene encoding thiamine transporter 2. To investigate the molecular mechanisms of neurodegeneration in SLC19A3 deficiency and whether administration of high-dose thiamine prevents neurodegeneration, we generated ...